The Galactosides of the Brain IV. The Constitution of Phrenosin and Kerasin.
نویسنده
چکیده
In the first communication of this series [1913, 2] I expressed the view that the brain contains in a preformed condition mainly two representatives of the group of glucosides, namely the galactosides phrenosin and kerasin, which were originally discovered by Thudichum. A new method for their preparation was subsequently described together with a physical test (the selenite plate test) which furnishes a reliable method for controlling the efficacy of the methods used for their separation [1914, 1]. In the following communication are given the experimental data obtained by the chemical and physical examination of the galactosides together with the results of complete hydrolysis experiments. The outcome of these experiments has been to establish for the first time the fact that kerasin possesses a laevorotation in distinction from the dextrorotatory phrenosin, and further that the only difference in chemical constitution of the two glucosides consists in their fatty acid component'. Whilst kerasin furnishes on hydrolysis inactive lignoceric acid (C24H4,02), phrenosin gives rise to the optically active hydroxy-acid phrenosinic acid (C25H5003). The near relationship of these fatty acids is evident from the interesting fact that phrenosinic acid furnishes lignoceric acid on oxidation [Levene and Jacobs, 1912, 2]. Both glucosides yield the same carbohydrate, d-galactose, and the same base, sphingosine (C.7H402N), on hydrolysis. These observations, together with the facts established by Levene and others with regard to the constitution of sphingosine, enable us now to construct constitutional formulae for these substances.
منابع مشابه
The Galactosides of the Brain. II. The Preparation of Phrenosin and Kerasin by the Pyridine Method.
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عنوان ژورنال:
- The Biochemical journal
دوره 10 1 شماره
صفحات -
تاریخ انتشار 2005